A mad doctor named Zanoff uses a drug to bring himself back from the dead after his execution in prison. Dick Tracy sets out to capture Zanoff before he can put his criminal gang back together again.

Western settlers are being driven off their homesteads and ranches by a combination of Indian raids and attacks by bands of mysterious outlaws. The government sends out famed Indian scout Kit Carson and army officer David Brent to investigate, and Carson discovers that a villain named Pegleg controls an outlaw gang called the Black Raiders, and is using them and the Indians to drive out the settlers so he can establish his own empire. He determines to set a trap to expose the identity of Pegleg while avoiding traps and ambushes that Pegleg is setting for him.

Dick Tracy battles spies and saboteurs in his efforts to bring to justice the Stark gang, a criminal family led by the vicious Pa Stark.

Larry Munro has discovered a vein of platinum on his ranch. A group known as the Secret Seven has learned about it and plan to get the Munro Ranch. Kentucky Wade and his friends arrive to help Larry and are soon fighting off attempts on their lives by the henchman of the Secret Seven and the Indians they enlist by bribing them with rifles.

An expedition arrives on an uncharted jungle island to rescue the local natives, led by a jungle boy, from a volcano that is about to erupt.

Pat Gallagher and his sidekick Stoney Crockett are Secret Service agents in the Old West, dispatched by the government to investigate crimes threatening the young nation.