Crime lord Jim Belmont escapes FBI custody and begins a reign of thievery that is thwarted at every turn by Jerry Blake, the FBI's Operator 99.

The Canadians have discovered a valuable substance called Compound X, which can cure infantile paralysis. When a country at war with Canada learns that Compound X also contains magnetic properties that could aid them in their warfare against the British, they send agents to infiltrate Canada and steal a large quantity of the substance. It's up to Sgt. King (Allan Lane) and his Mounties to track down the agents and put an end to their scheme.

A mad doctor named Zanoff uses a drug to bring himself back from the dead after his execution in prison. Dick Tracy sets out to capture Zanoff before he can put his criminal gang back together again.
Western settlers are being driven off their homesteads and ranches by a combination of Indian raids and attacks by bands of mysterious outlaws. The government sends out famed Indian scout Kit Carson and army officer David Brent to investigate, and Carson discovers that a villain named Pegleg controls an outlaw gang called the Black Raiders, and is using them and the Indians to drive out the settlers so he can establish his own empire. He determines to set a trap to expose the identity of Pegleg while avoiding traps and ambushes that Pegleg is setting for him.
Three government aviators called the "Flying G-Men", one of whom is disguised as "The Black Falcon", fight to protect the US and its allies from an enemy spy ring and to avenge the death of the fourth Flying G-Man.
Dick Tracy battles spies and saboteurs in his efforts to bring to justice the Stark gang, a criminal family led by the vicious Pa Stark.
Pat Gallagher and his sidekick Stoney Crockett are Secret Service agents in the Old West, dispatched by the government to investigate crimes threatening the young nation.

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