Foster (Charles Miller (IV)', owner of the local stagecoach line in Canyon City in the 1880s, has received a Federal Franchise Commission grant and is rushing to complete a new road through the lawless Comanche Strip with the aid of his daughter, June (Kay Aldridge), and his construction foreman "Red" Kelly (Eddie Acuff). Unbeknownst to them, their supposed friend, land-and-cattle dealer Martin Dexter (Robert Frazer), and the town lawyer, Silas Higby (Ted Adams), have plans of their own; should Foster's road see completion, homesteaders would occupy the strip and ruin Dexter's plans to buy the 500,000 acres for cattle-grazing land. Dester hires a band of renegade Indians to attack the road crew. Indian scout Jim Brady (Budd Buster)sees a supply wagon driver by "Red" and June being cased by the renegades, alerts the work-camp crew and then rides to summon Captain Duke Cameron (Allan Lane) and his U.S. Cavalry troop but, before they arrive, Foster has been killed along with many of his workmen. Cameron, a long-time friend of the Foster family, later requests his commanding officer, Colonel Andrews (Stanley Andrews) for a furlough to aid June in continuing her father's project. He then seeks to find out who is behind the renegade attack and, eleven cliffhangers later does so in the final chapter of this 12-chapter serial.

Dick Tracy goes up against a villain known as The Ghost, who can turn himself invisible.

Mountie sergeant and his three constables find themselves facing multiple perils at the hands of an outlaw gang which, aided by a corrupt Indian medicine man and his followers, have brought a halt to construction of a key railroad line through the Canadian Northwest.

Reporter Brenda Starr (Joan Woodbury) and her photographer Chuck Allen (Syd Saylor) get involved in a search for the loot from a payroll robbery. Cliffhanging action and adventure and a fair amount of comic relief follow them at every turn.

It's intrepid Nyoka and her friends versus Vultura, Queen of the Desert, on a quest for the Golden Tablets of Hippocrates.

Crime lord Jim Belmont escapes FBI custody and begins a reign of thievery that is thwarted at every turn by Jerry Blake, the FBI's Operator 99.

A mad doctor named Zanoff uses a drug to bring himself back from the dead after his execution in prison. Dick Tracy sets out to capture Zanoff before he can put his criminal gang back together again.

A 20th Century pilot named Buck Rogers and his young friend Buddy Wade awake from 500 years in suspended animation to find that the world has been taken over by the outlaw army of Killer Kane.

Three government aviators called the "Flying G-Men", one of whom is disguised as "The Black Falcon", fight to protect the US and its allies from an enemy spy ring and to avenge the death of the fourth Flying G-Man.

Dick Tracy battles spies and saboteurs in his efforts to bring to justice the Stark gang, a criminal family led by the vicious Pa Stark.