Foster (Charles Miller (IV)', owner of the local stagecoach line in Canyon City in the 1880s, has received a Federal Franchise Commission grant and is rushing to complete a new road through the lawless Comanche Strip with the aid of his daughter, June (Kay Aldridge), and his construction foreman "Red" Kelly (Eddie Acuff). Unbeknownst to them, their supposed friend, land-and-cattle dealer Martin Dexter (Robert Frazer), and the town lawyer, Silas Higby (Ted Adams), have plans of their own; should Foster's road see completion, homesteaders would occupy the strip and ruin Dexter's plans to buy the 500,000 acres for cattle-grazing land. Dester hires a band of renegade Indians to attack the road crew. Indian scout Jim Brady (Budd Buster)sees a supply wagon driver by "Red" and June being cased by the renegades, alerts the work-camp crew and then rides to summon Captain Duke Cameron (Allan Lane) and his U.S. Cavalry troop but, before they arrive, Foster has been killed along with many of his workmen. Cameron, a long-time friend of the Foster family, later requests his commanding officer, Colonel Andrews (Stanley Andrews) for a furlough to aid June in continuing her father's project. He then seeks to find out who is behind the renegade attack and, eleven cliffhangers later does so in the final chapter of this 12-chapter serial.

Dick Tracy goes up against a villain known as The Ghost, who can turn himself invisible.

A sea captain about to be hanged for a murder he didn't commit is rescued from the gallows by two of his crewmen. They head for the island of Pulinan, where they believe the real murderer--the captain's former partner--is hiding so the captain can clear his name. As it turns out, their troubles are only beginning.

Crime lord Jim Belmont escapes FBI custody and begins a reign of thievery that is thwarted at every turn by Jerry Blake, the FBI's Operator 99.

A mad doctor named Zanoff uses a drug to bring himself back from the dead after his execution in prison. Dick Tracy sets out to capture Zanoff before he can put his criminal gang back together again.

Three government aviators called the "Flying G-Men", one of whom is disguised as "The Black Falcon", fight to protect the US and its allies from an enemy spy ring and to avenge the death of the fourth Flying G-Man.

Dick Tracy battles spies and saboteurs in his efforts to bring to justice the Stark gang, a criminal family led by the vicious Pa Stark.

An expedition arrives on an uncharted jungle island to rescue the local natives, led by a jungle boy, from a volcano that is about to erupt.

A famous detective sets out to discover who stole $2 million in bonds.

A young radio cop and a beautiful girl try to stop an international criminal gang from getting their hands on the formula for a new bulletproof steel.

A scientist invents a poison gas; the villain and his gang will do anything to get the formula; our hero, "Lightning Hutch", is sent to save the scientist, the scientist's beautiful daughter, and the formula.

Ken Williams is determined to discover the identity of the mysterious Rattler, who preys upon railroads and transportation companies like that owned by Jane Corwin. The Rattler is especially difficult to catch because of his skill at disguising himself as other people.