Young Pauline is left a lot of money when her wealthy uncle dies. However, her uncle's secretary has been named as her guardian until she marries, at which time she will officially take possession of her inheritance. Meanwhile, her "guardian" and his confederates constantly come up with schemes to get rid of Pauline so that he can get his hands on the money himself.

Nat Cutler, known as Hawkeye, is a fur trader. With his faithful Indian companion Chingachgook, the last of the Mohican tribe, he fights to protect settlers against the raiding Huron Indians.

Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.

Beyond Hell's Gate Pass is territory controlled by a man who calls himself King Carter; he uses a variety of schemes to prevent the railroad from being built, for fear it will finish his control of (what he considers) his land.

A murderous gang of counterfeiters has kidnapped the government's best engraver and is forcing him to print virtually undetectable phony money. The Secret Service sends its toughest agent, Jack Holt, and a female partner after the gang.

Produced at the same time as the more well-known The Twilight Zone (1959), this series was an extension of the tradition of radio horror and supernatural dramas such as Light's Out, The Mysterious Traveler and The Witches Tale. As with the Twilight Zone and the radio programs each tale was book-ended by an introduction and conclusion by a host. However, rather than creating fictional stories with supernatural twists and turns, this program sought out "real" stories of the supernatural, including ghosts, disappearances, monsters and the like, re-creating them for each episode. No solutions to these mysteries were ever found, and viewers could only scratch their heads and wonder, "what if it's real?"

Crash Corrigan, a recent graduate of Annapolis, and Diana, a go-getting reporter, join Professor Norton for a search for the source of a string of earthquakes, Atlantis. They ride Prof. Norton's rocket submarine searching the sea and little Billy Norton, the professor's son stows away, of course. When they find Atlantis they are caught in a war between peaceful Atlanteans, note their white capes, and war-monging Atlanteans, note their black capes. After many harrowing moments for Crash, Diana, Prof. Norton and Billy, they barely get away with their lives when they escape a tower of Atlantis raised to the surface for the sole purpose of dominating or destroying the Earth (Which one depends on the compliance of the upper world dwellers.)

Police detectives battle the League of Murdered Men, a gang of resurrected dead criminals.