The adventures of a small town doctor working in the Arizona territory during the early 1900s.

In 1865, Captain Mark Smith of the Confederate Army leads a band of deserters to conquer Texas and rule it as a dictator. In one of his first actions, he captures and assumes the identity of Texas' new Finance Commissioner, Colonel Marcus Jeffries, after having the real man murdered. When a contingent of Texas Rangers enters the territory, Snead, one of Smith's men, leads them into an ambush by Smith's "troopers". The Rangers are apparently wiped out, although one injured survivor is left. The survivor, nursed back to health by Tonto, swears to avenge the massacre and defeat "Colonel Jeffries" and his men.

Tom Grant has found a rich gold vein and Bart Eaton is after it. Tom's sister Mary heads for the gold fields and Eaton and his men follow. Eaton teams up with Ace Daggett who plans to doublecross him and get the gold for himself. They frame Tom for murder and then try to get him to sign over his claim. The famous scout Tex Houston is on hand, escaping the attempts on his life, saving Mary from various perils, and trying to bring in the real killer and clear Tom.

Railroad detective Matt Clark roams the west, tracking down outlaws and bandits who are preying on the railroad.